Hydrochloric Acid → HCID 69069996, compound

HRID 1435945Notes

Reaction equation

HRID 1435945 reaction equation
C[O:2][C:3]([CH:5]1[N:12]2[C:8](=[N:9][NH:10][C:11]2=[O:13])[CH2:7][CH2:6]1)=[O:4].[Li+].[OH-].Cl>C1COCC1.O>[O:13]=[C:11]1[NH:10][N:9]=[C:8]2[CH2:7][CH2:6][CH:5]([C:3]([OH:4])=[O:2])[N:12]12

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 69077734HCID 69077734, compound

Product 1

HCID 69069996HCID 69069996, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent2×

Procedure

3-Oxo-2,5,6,7-tetrahydro-3H-pyrrolo[2,1-c][1,2,4]triazole-5-carboxylic acid methyl ester (0.50 g, 2.7 mmol) was dissolved in THF (3.0 mL). LiOH (0.14 g, 3.3 mmol) was dissolved in water (3.0 mL), which was added to the THF mixture and stirred at room temperature for 30 min. The mixture was acidified with 1N HCl and extracted with DCM. The organic layers were dried over MgSO4, filtered through CELITE®, and concentrated in vacuo to give 3-Oxo-2,5,6,7-tetrahydro-3H-pyrrolo[2,1-c][1,2,4]triazole-5-carboxylic acid.

Workup

  1. extractionextracted with DCM
  2. dry with materialThe organic layers were dried over MgSO4
  3. filtrationfiltered through CELITE®
  4. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-99be93e0bffb48958cf653b0899eb7a6
Source dataset
uspto-grants-2009_11
Patent number
US07618983B2

Reaction notes

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