Lithium Hydroxide → 4-Azido-3-[[(1,1-dimethylethoxy)carbonyl]amino]butanoic acid

HRID 1435955Notes

Reaction equation

HRID 1435955 reaction equation
C[O:2][C:3](=[O:18])[CH2:4][CH:5]([NH:10][C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12])[CH2:6][N:7]=[N+:8]=[N-:9].[Li+].[OH-]>C1COCC1>[N:7]([CH2:6][CH:5]([NH:10][C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12])[CH2:4][C:3]([OH:18])=[O:2])=[N+:8]=[N-:9]

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 57938929HCID 57938929, compound

Product 1

HCID 579389304-Azido-3-[[(1,1-dimethylethoxy)carbonyl]amino]butanoic acid

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

DL-4-azido-3-tert-butoxycarbonylamino-butyric acid methyl ester (450 mg, 1.74 mmol) was dissolved in THF (12 mL) and hydrolized by adding an aqueous solution of LiOH (393 mg).

Sources & evidence

ORD record
ord-15ac9e3f64d24f738cddb9f1e53b4811
Source dataset
uspto-grants-2009_11
Patent number
US07618982B2

Reaction notes

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