反应详情

温度

60 °C

To a solution of compound 3 (5.307 g, 18 mmol) in DMF (15 mL) was added K2CO3 (3.73 g, 27 mmol) and iodoethane (3.5 mL, 43.2 mmol). The resulting mixture was stirred at 60° C. for three hours. The mixture was diluted with water and extracted with EtOAc (3×50 mL). The organic layers were combined, dried over Na2SO4, and concentrated. Purification with column chromatography (Hexanes/EtOAc 50:50) gave the product 4 (3.2 g, 55%) as white solid.

1. extractionextracted with EtOAc (3×50 mL)
2. dry with materialdried over Na2SO4
3. concentrationconcentrated
4. customPurification with column chromatography (Hexanes/EtOAc 50:50)