Methylamine → (5-Methylcarbamoyl-[1,3,4]oxadiazol-2-ylmethyl)carbamic acid tert-butyl ester

HRID 1437144Notes

Reaction equation

HRID 1437144 reaction equation
C(O[C:4]([C:6]1[O:7][C:8]([CH2:11][NH:12][C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])=[N:9][N:10]=1)=[O:5])C.[CH3:20][NH2:21]>C1COCC1>[C:16]([O:15][C:13](=[O:14])[NH:12][CH2:11][C:8]1[O:7][C:6]([C:4](=[O:5])[NH:21][CH3:20])=[N:10][N:9]=1)([CH3:17])([CH3:18])[CH3:19]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 10084542Ethyl 5-(((tert-butoxycarbonyl)amino)methyl)-1,3,4-oxadiazole-2-carboxylate

Product 1

HCID 11777159(5-Methylcarbamoyl-[1,3,4]oxadiazol-2-ylmethyl)carbamic acid tert-butyl ester

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Prepared in an analogous fashion to Description 35 from 5-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-1,3,4-oxadiazole-2-carboxylic acid ethyl ester (prepared as described in JOC (1995), 60(10), 3112-20) (0.150 g) using 2.0M methylamine in THF.

Sources & evidence

ORD record
ord-1faecd064f4c494290368abf29dc8b0d
Source dataset
uspto-grants-2009_11
Patent number
US07622464B2

Reaction notes

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