Methyl iodide → HCID 68701081, compound

HRID 1437348Notes

Reaction equation

HRID 1437348 reaction equation
[C:1]([CH2:4][O:5][C:6]1[C:7]([N+:14]([O-:16])=[O:15])=[CH:8][C:9]([CH3:13])=[N+:10]([O-:12])[CH:11]=1)([OH:3])=[O:2].[C:17](=O)([O-])[O-].[K+].[K+].IC>CN(C=O)C>[CH3:17][O:2][C:1]([CH2:4][O:5][C:6]1[C:7]([N+:14]([O-:16])=[O:15])=[CH:8][C:9]([CH3:13])=[N+:10]([O-:12])[CH:11]=1)=[O:3]

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 68700280HCID 68700280, compound

Product 1

HCID 68701081HCID 68701081, compoundYield 59.7%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The carboxylic acid (c) (8.4 g) in DMF (100 ml) was treated with potassium carbonate (7.6 g) and iodomethane (2.8 ml) and stirred for 3 days. After evaporation of solvent, water (200 ml) was added and the solid filtered off and dried under vacuum to give the product (5.32 g).

Workup

  1. customAfter evaporation of solvent, water (200 ml)
  2. additionwas added
  3. filtrationthe solid filtered off
  4. customdried under vacuum

Sources & evidence

ORD record
ord-1c3d32bde913485d9051e61f0e19c5ec
Source dataset
uspto-grants-2009_11
Patent number
US07622481B2

Reaction notes

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