反应详情

A solution of ethyl mercaptoacetate (1.15 ml) in DMF (40 ml) was ice-cooled under argon, treated with sodium hydride (420 mg of a 60% dispersion in oil) and stirred until all was in solution (about 1 hour). The ester (a) (2.48 g) was added, the mixture allowed to warm to room temp. and stirred overnight. EtOAc (150 ml) was added, the solution washed with water (3×150 ml), dried and evaporated. Chromatography of the residue (40% EtOAc in hexane) gave an oil (1.7 g).

1. temperaturecooled under argon
2. customall was in solution (about 1 hour)
3. temperatureto warm to room temp.
4. stirringstirred overnight
5. washthe solution washed with water (3×150 ml)
6. customdried
7. customevaporated