Tetrahydrofuran → HCID 21873620, compound

HRID 1437354Notes

Reaction equation

HRID 1437354 reaction equation
[F:1][C:2]1[C:11]([CH2:12][OH:13])=[N:10][C:9]2[NH:8][C:7](=[O:14])[CH2:6][S:5][C:4]=2[CH:3]=1.C1COCC1>[O-2].[O-2].[Mn+4].ClCCCl>[F:1][C:2]1[C:11]([CH:12]=[O:13])=[N:10][C:9]2[NH:8][C:7](=[O:14])[CH2:6][S:5][C:4]=2[CH:3]=1

Participants

5

Reactant 2

HCID 8028TetrahydrofuranHCID 21873626HCID 21873626, compound

Product 1

HCID 21873620HCID 21873620, compound

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 111,2-DichloroethaneSolvent

Conditions

Temperature
60 °C

Procedure

A mixture of the alcohol (e) (971 mg), manganese dioxide (3.72 g), THF (70 ml) and 1,2-dichloroethane (70 ml) was heated at 60° C. under argon for 20 hours. Filtration through kieselguhr and evaporation of solvent gave a solid which was triturated with EtOAc/hexane 1:3 and collected by filtration (608 mg).

Workup

  1. filtrationFiltration
  2. customthrough kieselguhr and evaporation of solvent
  3. customgave a solid which
  4. customwas triturated with EtOAc/hexane 1:3
  5. filtrationcollected by filtration (608 mg)

Sources & evidence

ORD record
ord-82ecf590619c4e0eaecbca126800a9e7
Source dataset
uspto-grants-2009_11
Patent number
US07622481B2

Reaction notes

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