Glycolide → HCID 6453016, compound

HRID 1437784Notes

Reaction equation

HRID 1437784 reaction equation
[CH2:1]1[O:8]C(=O)C[O:4][C:2]1=[O:3].[CH3:9][C@@H:10]1[O:17]C(=O)[C@H](C)[O:13][C:11]1=[O:12]>O>[C:2]([OH:4])(=[O:3])[CH2:1][OH:8].[C:11]([OH:13])(=[O:12])[C@H:10]([CH3:9])[OH:17]

Participants

4

Reactant 2

HCID 65432GlycolideHCID 107983Lactide, L-

Product 1

HCID 6453016HCID 6453016, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

An operation was conducted in the same manner as in Example 13 except that 22,050 g (glycolic acid: 70 ppm, glycolic acid dimer: 360 ppm, water: 20 ppm; overall proton concentration of impurities: 0.054 mol %) of glycolide and 450 g (lactic acid: 0 ppm, lactic acid dimer: 270 ppm, water: 8 ppm; overall proton concentration of impurities: 0.030 mol %) of L-lactide were used, and 2.06 g [in view of the amount (0.36 g) of water (moisture) contained in an atmosphere within the container] of water were added to control the overall proton concentration (set proton concentration) to 0.124 mol %. After completion of the polymerization, the yield of bulk matter of a poly(glycolic acid/L-lactic acid) copolymer formed was almost 100%. The bulk matter was ground by a grinder, and the physical properties of the ground product were measured. The results are shown in Table 5.

Workup

  1. additionwere added
  2. concentrationthe overall proton concentration (set proton concentration) to 0.124 mol %
  3. customAfter completion of the polymerization

Sources & evidence

ORD record
ord-b871444c353547ca8baae072ae1d68f9
Source dataset
uspto-grants-2009_11
Patent number
US07622546B2

Reaction notes

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