Potassium Cyanide → HCID 59838024, compound

HRID 1438164Notes

Reaction equation

HRID 1438164 reaction equation
[F:1][C:2]1[CH:9]=[CH:8][C:7]([Cl:10])=[CH:6][C:3]=1[CH:4]=[O:5].[C-:11]#[N:12].[K+].OS([O-])=O.[Na+]>C(OCC)(=O)C.O>[F:1][C:2]1[CH:9]=[CH:8][C:7]([Cl:10])=[CH:6][C:3]=1[CH:4]([OH:5])[C:11]#[N:12]

Participants

6

Reactant 3

HCID 9032Potassium CyanideHCID 27735865-Chloro-2-fluorobenzaldehydeHCID 23665763Sodium Bisulfite

Product 1

HCID 59838024HCID 59838024, compoundYield 99%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8857Ethyl AcetateSolvent

Procedure

To 2-fluoro-5-chloro-benzaldehyde (12.7 g, 17 mmol) in ethyl acetate (50 mL) was added a solution of KCN (3.3 g) and NaHSO3 (5.3 g) dissolved in H2O (25 mL). It was left stirring overnight before extracted with ethyl acetate (3×50 mL). The combined organic extracts were dried and concentrated. The crude product was purified by silica gel chromatography to give 121A (3.1 g, 99% yield) as an oil.

Workup

  1. waitIt was left
  2. extractionbefore extracted with ethyl acetate (3×50 mL)
  3. customThe combined organic extracts were dried
  4. concentrationconcentrated
  5. customThe crude product was purified by silica gel chromatography

Sources & evidence

ORD record
ord-cf95786ca4aa486894d4ba0e3da819bb
Source dataset
uspto-grants-2009_11
Patent number
US07622585B2

Reaction notes

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