反应详情

A mixture of 80 g. 2-chlorobenzoic acid, 80 g. 4-anisidine, 80 g. potassium carbonate, 4 g. activated copper powder, and 800 ml. amyl alcohol was heated under reflux with efficient stirring for 4 hours. The amyl alcohol was removed by steam distillation and the remaining aqueous phase was filtered and made neutral by addition of 1:1 concentrated hydrochloric acid-water. The resulting solid (102 g.) was collected by filtration to give after recrystallization from isopropyl alcohol N-(4-methoxyphenyl)anthranilic acid; m.p. 183°-184° C.

1. additionA mixture of 80 g
2. temperatureunder reflux
3. customThe amyl alcohol was removed by steam distillation
4. filtrationthe remaining aqueous phase was filtered
5. additionmade neutral by addition of 1:1 concentrated hydrochloric acid-water
6. filtrationThe resulting solid (102 g.) was collected by filtration
7. customto give
8. customafter recrystallization from isopropyl alcohol N-(4-methoxyphenyl)anthranilic acid