Hydrogen Bromide → Benzenepropanol, β-amino-3-hydroxy-, hydrobromide (1:1)

HRID 1439263Notes

Reaction equation

HRID 1439263 reaction equation
Cl.Cl.[NH2:3][CH:4]([CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([O:14]C)[CH:9]=1)[CH2:5][OH:6].[BrH:16]>>[BrH:16].[NH2:3][CH:4]([CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([OH:14])[CH:9]=1)[CH2:5][OH:6]

Participants

4

Reactant 3

HCID 260Hydrogen BromideHCID 313Hydrochloric AcidHCID 21398994HCID 21398994, compound

Product 1

HCID 21399008Benzenepropanol, β-amino-3-hydroxy-, hydrobromide (1:1)

Procedure

8 gm of the hydrochloride obtained in (a) were admixed with 80 ml of 48% hydrobromic acid, and the mixture was refluxed for one hour. Thereafter, the reaction mixture was evaporated to dryness, the residue was stripped of water by entrainment with xylene, the solvent was distilled off, and the residue was recrystallized from ethyl acetate, yielding 6 gm (66% of theory) of the compound of the formula ##STR9## which had a melting point of 150°-152° C.

Workup

  1. temperaturethe mixture was refluxed for one hour
  2. customThereafter, the reaction mixture was evaporated to dryness
  3. distillationthe solvent was distilled off
  4. customthe residue was recrystallized from ethyl acetate
  5. customyielding 6 gm (66% of theory) of the compound of the formula ##STR9## which

Sources & evidence

ORD record
ord-c8d6d06b0ba54d4ca0663bb872b83659
Source dataset
uspto-grants-1977_11
Patent number
US04058642

Reaction notes

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