Diethylamine → HCID 21396817, compound

HRID 1439332Notes

Reaction equation

HRID 1439332 reaction equation
[CH2:1]([O:3][C:4]1[C:8]([C:9]([O:11][CH2:12][CH3:13])=[O:10])=[C:7]([NH:14][C:15](=[O:23])OC2C=CC=CC=2)[S:6][N:5]=1)[CH3:2].[CH2:24]([NH:26][CH2:27][CH3:28])[CH3:25]>CN(C)C=O>[CH2:24]([N:26]([CH2:27][CH3:28])[C:15]([NH:14][C:7]1[S:6][N:5]=[C:4]([O:3][CH2:1][CH3:2])[C:8]=1[C:9]([O:11][CH2:12][CH3:13])=[O:10])=[O:23])[CH3:25]

Participants

4

Reactant 2

HCID 8021DiethylamineHCID 54353810HCID 54353810, compound

Product 1

HCID 21396817HCID 21396817, compoundYield 40.6%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In the manner of Example II B, 8.4 g of phenyl (3-ethoxy-4-ethoxycarbonyl-5-isothiazolyl)carbamate in 20 ml of dimethylformamide were allowed to react with 3.7 g of diethylamine. The solid from the reaction mixture was recrystallized from ethanol:water (70:30) to give 3.2 g of 1,1-diethyl-3-(3-ethoxy-4-ethoxycarbonyl-5-isothiazolyl)urea, m.p. 77°-80°. The nmr spectrum was consistent with the assigned structure.

Workup

  1. customThe solid from the reaction mixture was recrystallized from ethanol:water (70:30)

Sources & evidence

ORD record
ord-69c06a35e54f42e8aabd8389e31f3766
Source dataset
uspto-grants-1977_11
Patent number
US04059433

Reaction notes

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