Tri-o-tolylphosphine → HCID 22859579, compound

HRID 1441064Notes

Reaction equation

HRID 1441064 reaction equation
[C:1]([C:4]1[CH:5]=[C:6]([Sn](CCCC)(CCCC)CCCC)[CH:7]=[N:8][CH:9]=1)(=[O:3])[NH2:2].Br[C:24]1[CH:25]=[C:26]2[C:30](=[CH:31][CH:32]=1)[NH:29][CH:28]=[C:27]2[CH2:33][C@H:34]1[CH2:38][CH2:37][CH2:36][N:35]1[CH2:39][CH:40]1[CH2:42][CH2:41]1.C1(C)C=CC=CC=1P(C1C=CC=CC=1C)C1C=CC=CC=1C>C([O-])(=O)C.[Pd+2].C([O-])(=O)C.C(N(CC)CC)C>[C:1]([C:4]1[CH:5]=[C:6]([C:24]2[CH:25]=[C:26]3[C:30](=[CH:31][CH:32]=2)[NH:29][CH:28]=[C:27]3[CH2:33][C@H:34]2[CH2:38][CH2:37][CH2:36][N:35]2[CH2:39][CH:40]2[CH2:42][CH2:41]2)[CH:7]=[N:8][CH:9]=1)(=[O:3])[NH2:2]

Participants

6

Reactant 3

HCID 80271Tri-o-tolylphosphineHCID 22420973HCID 22420973, compoundHCID 22859588HCID 22859588, compound

Product 1

HCID 22859579HCID 22859579, compound

Reagents, catalysts & solvents 2

HCID 167845palladium(II) acetateCatalystHCID 8471TriethylamineSolvent

Procedure

5-Carbamoyl-3-pyridyltri-n-butylstannane (see Preparation 43) and 5-bromo-3-(1-cyclopropylmethylpyrrolidin-2(R)-ylmethyl)-1H-indole (see Preparation 56) were reacted together in the presence of palladium (II) acetate, tri-o-tolylphosphine and triethylamine using a procedure similar to that described in Example 1. This yielded the title compound. Found: C,71.56; H,7.13; N,13.72. C23H26N4O.3/16CH2Cl2 requires: C,71.33; H,6.,81; N,14.35%.

Sources & evidence

ORD record
ord-42116d2967e542a2bc9743731558bc87
Source dataset
uspto-grants-1996_03
Patent number
US05502065

Reaction notes

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