Methyl iodide → HCID 44591734, compound

HRID 1441235Notes

Reaction equation

HRID 1441235 reaction equation
[Cl:1][C:2]1[CH:29]=[C:28]([Cl:30])[CH:27]=[CH:26][C:3]=1[C:4]([NH:6][CH2:7][C:8]1([CH2:22][CH:23]2[CH2:25][CH2:24]2)[CH2:13][CH2:12][N:11]([S:14]([C:17]2[N:18]=[N:19][NH:20][CH:21]=2)(=[O:16])=[O:15])[CH2:10][CH2:9]1)=[O:5].[C:31](=O)([O-])[O-].[K+].[K+].CI>CN(C)C=O>[Cl:1][C:2]1[CH:29]=[C:28]([Cl:30])[CH:27]=[CH:26][C:3]=1[C:4]([NH:6][CH2:7][C:8]1([CH2:22][CH:23]2[CH2:24][CH2:25]2)[CH2:13][CH2:12][N:11]([S:14]([C:17]2[N:18]=[N:19][N:20]([CH3:31])[CH:21]=2)(=[O:15])=[O:16])[CH2:10][CH2:9]1)=[O:5]

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 178522752HCID 178522752, compound

Product 1

HCID 44591734HCID 44591734, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

2,4-Dichloro-N-[4-(cyclopropylmethyl)-1-(1H-[1,2,3]triazole-4-sulfonyl)piperidin-4-ylmethyl]benzamide (472 mg, 1.0 mmol) was dissolved in N,N-dimethylformamide (5 mL). Potassium carbonate (276 mg, 2 mmol) and methyl iodide (81 μL, 1.3 mmol) were added and the mixture stirred at room temperature over night.

Sources & evidence

ORD record
ord-74357077942943cdbbbbc0e3ce23eaf7
Source dataset
uspto-grants-2010_02
Patent number
US07655644B2

Reaction notes

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