反应详情

To a suspension of hydroxypivalic acid (3 g) and potassium carbonate (3.9 g) in N,N-dimethylformamide (25 mL) was added benzyl bromide (2.9 mL), and the mixture was stirred at room temperature for 5 hours. The reaction mixture was poured into water, and the resulting mixture was extracted with diethyl ether. The organic layer was washed with water twice and dried over anhydrous magnesium sulfate. The solvent was removed under reduced pressure to give the title compound (4.7 g).

1. extractionthe resulting mixture was extracted with diethyl ether
2. washThe organic layer was washed with water twice
3. dry with materialdried over anhydrous magnesium sulfate
4. customThe solvent was removed under reduced pressure