1,2-Dichloroethane → HCID 11590207, compound

HRID 1442690Notes

Reaction equation

HRID 1442690 reaction equation
[CH3:1][C:2]([CH3:32])([CH3:31])[C:3](=[O:30])[CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]([C:17]2[O:18][C:19]3[CH:25]=[CH:24][C:23]([C:26]([OH:28])=O)=[CH:22][C:20]=3[N:21]=2)([CH2:15][CH3:16])[CH2:13][CH3:14])=[CH:8][C:7]=1[CH3:29].C(Cl)CCl.[NH4+:37]>CN(C1C=CN=CC=1)C>[CH3:32][C:2]([CH3:1])([CH3:31])[C:3](=[O:30])[CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]([C:17]2[O:18][C:19]3[CH:25]=[CH:24][C:23]([C:26]([NH2:37])=[O:28])=[CH:22][C:20]=3[N:21]=2)([CH2:15][CH3:16])[CH2:13][CH3:14])=[CH:8][C:7]=1[CH3:29]

Participants

5

Reactant 3

HCID 111,2-DichloroethaneHCID 223AmmoniumHCID 11597308HCID 11597308, compound

Product 1

HCID 11590207HCID 11590207, compoundYield 7%

Reagents, catalysts & solvents 1

HCID 142844-(Dimethylamino)pyridineCatalyst

Procedure

2-{1-[4-(3,3-Dimethyl-2-oxo-butoxy)-3-methyl-phenyl]-1-ethyl-propyl}-benzooxazole-5-carboxylic acid (150 mg, 0.343 mmol), DMAP (125 mg, 1.03 mmol) and EDC (99 mg, 0.514 mmol) and aqueous ammonium hydrroxide (1.0 mL, 30%) is reacted analogous to Example 2 to give the title product (10 mg, 7%). MS (ES) m/e: 437.3 (M+1).

Sources & evidence

ORD record
ord-e4d59782bd5f4b2eac4ac1441572e647
Source dataset
uspto-grants-2010_02
Patent number
US07659296B2

Reaction notes

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