Trifluoroacetic acid → HCID 68411844, compound

HRID 1443485Notes

Reaction equation

HRID 1443485 reaction equation
C([O:5][C:6]([CH:8]1[CH2:12][CH:11]([O:13][C:14]2[C:23]3[C:18](=[C:19]([CH3:26])[C:20]([O:24][CH3:25])=[CH:21][CH:22]=3)[N:17]=[C:16]([C:27]3[CH:32]=[CH:31][C:30]([O:33][CH3:34])=[CH:29][CH:28]=3)[N:15]=2)[CH2:10][CH:9]1[C:35](=[O:47])[NH:36][C:37]1([C:42]([O:44][CH2:45][CH3:46])=[O:43])[CH2:39][CH:38]1[CH:40]=[CH2:41])=[O:7])(C)(C)C.C(O)(C(F)(F)F)=O>ClCCl.C([SiH](CC)CC)C>[CH2:45]([O:44][C:42]([C:37]1([NH:36][C:35]([CH:9]2[CH2:10][CH:11]([O:13][C:14]3[C:23]4[C:18](=[C:19]([CH3:26])[C:20]([O:24][CH3:25])=[CH:21][CH:22]=4)[N:17]=[C:16]([C:27]4[CH:28]=[CH:29][C:30]([O:33][CH3:34])=[CH:31][CH:32]=4)[N:15]=3)[CH2:12][CH:8]2[C:6]([OH:7])=[O:5])=[O:47])[CH2:39][CH:38]1[CH:40]=[CH2:41])=[O:43])[CH3:46]

Participants

5

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68411553HCID 68411553, compound

Product 1

HCID 68411844HCID 68411844, compoundYield 88.2%

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 12052TriethylsilaneSolvent

Procedure

Compound 133 (915 mg, 1.417 mmol) was dissolved in dichloromethane (20 mL) and triethylsilane (0.56 mL). TFA (20 ml) was added dropwise at room temperature and the mixture was left for 3 h at room temperature. Removal of the solvent gave the title compound (737 mg, 88%) MS (M+H)+ 590.

Workup

  1. customRemoval of the solvent

Sources & evidence

ORD record
ord-6ad5030f4ecb4f959fb237549ae1c005
Source dataset
uspto-grants-2010_02
Patent number
US07659245B2

Reaction notes

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