Sodium hydride → HCID 68786969, compound

HRID 1443617Notes

Reaction equation

HRID 1443617 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([C:14]#[N:15])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.[H-].[Na+].Br[CH2:19][CH2:20][CH2:21][CH2:22][OH:23]>CN(C)C=O>[OH:23][CH2:22][CH2:21][CH2:20][CH2:19][NH:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:13]=[CH:12][C:11]([C:14]#[N:15])=[CH:10][CH:9]=2)=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 971934-Amino-4'-cyanobiphenylHCID 1183884-Bromobutanol

Product 1

HCID 68786969HCID 68786969, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

4′-amino-(1,1′-Biphenyl)-4-carbonitrile is dissolved in dimethyl formamide. Sodium hydride is added to the solution followed by 4-bromo-1-hydroxybutane to provide 4′-(4-hydroxybutylamino)-(1,1′-Biphenyl)-4-carbonitrile. 4′-(4-hydroxybutylamino)-(1,1′-Biphenyl)-4-carbonitrile is suspended in dichloromethane.

Sources & evidence

ORD record
ord-33d0127aafd44e1a8c151baec86d18ff
Source dataset
uspto-grants-2010_02
Patent number
US07662572B2

Reaction notes

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