Hydrochloric Acid → HCID 59168137, compound

HRID 1444013Notes

Reaction equation

HRID 1444013 reaction equation
C[O:2][C:3](=[O:31])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([CH2:10][O:11][C:12]2[C:17]([NH:18][S:19]([C:22]3[CH:27]=[CH:26][CH:25]=[C:24]([Cl:28])[C:23]=3[Cl:29])(=[O:21])=[O:20])=[N:16][CH:15]=[C:14]([Cl:30])[N:13]=2)[CH:5]=1.O.[OH-].[Li+].Cl>O.CO>[Cl:30][C:14]1[N:13]=[C:12]([O:11][CH2:10][C:6]2[CH:5]=[C:4]([CH:9]=[CH:8][CH:7]=2)[C:3]([OH:31])=[O:2])[C:17]([NH:18][S:19]([C:22]2[CH:27]=[CH:26][CH:25]=[C:24]([Cl:28])[C:23]=2[Cl:29])(=[O:20])=[O:21])=[N:16][CH:15]=1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 168937Lithium hydroxide, monohydrateHCID 59168168HCID 59168168, compound

Product 1

HCID 59168137HCID 59168137, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

A mixture of 3-[6-chloro-3-(2,3-dichlorobenzenesulphonylamino)-2-pyrazinyloxymethyl]benzoic acid methyl ester (Example 104) (0.3 g) and lithium hydroxide hydrate (0.2 g) in water (5 mL) and methanol (5 mL) was stirred at room temperature. After 3 h, hydrochloric acid (2M) was added to acidify the mixture and the solid product was collected by filtration and dried (0.25 g).

Workup

  1. filtrationthe solid product was collected by filtration
  2. customdried (0.25 g)

Sources & evidence

ORD record
ord-d63b9bdd8e3649aa8a31f80acdef4f70
Source dataset
uspto-grants-2010_02
Patent number
US07662825B2

Reaction notes

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