3-Pyridinemethanol → HCID 59168095, compound

HRID 1444027Notes

Reaction equation

HRID 1444027 reaction equation
Cl[C:2]1[C:3]([NH2:8])=[N:4][CH:5]=[CH:6][N:7]=1.[N:9]1[CH:14]=[CH:13][CH:12]=[C:11]([CH2:15][OH:16])[CH:10]=1.[H-].[Na+]>CN1CCCC1=O>[N:9]1[CH:14]=[CH:13][CH:12]=[C:11]([CH2:15][O:16][C:2]2[C:3]([NH2:8])=[N:4][CH:5]=[CH:6][N:7]=2)[CH:10]=1

Participants

5

Reactant 3

HCID 75103-PyridinemethanolHCID 24758Sodium hydrideHCID 2762242-Amino-3-chloropyrazine

Product 1

HCID 59168095HCID 59168095, compoundYield 79.7%

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

Prepared as for Example 121a using 3-chloro-2-aminopyrazine (0.5 g), pyridine-3-methanol (0.42 g) and sodium hydride (0.31 g of a 60% dispersion in oil) in N-methylpyrrolidinone (5 mL) to afford the sub-titled compound as a solid (0.62 g).

Workup

  1. customPrepared as for Example 121a

Sources & evidence

ORD record
ord-06c2536f581d42fbbf532cb7173b86be
Source dataset
uspto-grants-2010_02
Patent number
US07662825B2

Reaction notes

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