2,6-Pyridinedimethanol → 2,3-Dichloro-N-[5-chloro-3-{[6-(hydroxymethyl)-2-pyridinyl]methoxy}-2-pyrazinyl]benzenesulphonamide

HRID 1444045Notes

Reaction equation

HRID 1444045 reaction equation
[OH:1][CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([CH2:9][OH:10])[N:4]=1.[Cl:11][C:12]1[C:17]([Cl:18])=[CH:16][CH:15]=[CH:14][C:13]=1[S:19]([NH:22][C:23]1[C:28](Cl)=[N:27][C:26]([Cl:30])=[CH:25][N:24]=1)(=[O:21])=[O:20]>CN1CCCC1=O>[Cl:11][C:12]1[C:17]([Cl:18])=[CH:16][CH:15]=[CH:14][C:13]=1[S:19]([NH:22][C:23]1[C:28]([O:1][CH2:2][C:3]2[CH:8]=[CH:7][CH:6]=[C:5]([CH2:9][OH:10])[N:4]=2)=[N:27][C:26]([Cl:30])=[CH:25][N:24]=1)(=[O:21])=[O:20]

Participants

4

Reactant 2

HCID 709572,6-PyridinedimethanolHCID 101263402,3-dichloro-N-(3,5-dichloro-2-pyrazinyl)benzenesulphonamide

Product 1

HCID 591681432,3-Dichloro-N-[5-chloro-3-{[6-(hydroxymethyl)-2-pyridinyl]methoxy}-2-pyrazinyl]benzenesulphonamide

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

Prepared by the method of Example 31 using 2,6-bis(hydroxymethyl)pyridine (0.11 g) and 2,3-dichloro-N-(3,5-dichloro-2-pyrazinyl)benzenesulphonamide (Example 74) (0.11 g) in N-methylpyrrolidinone (2 mL). Yield 0.043 g.

Sources & evidence

ORD record
ord-9d8b66e27b574eb4a11cfa6026cd6402
Source dataset
uspto-grants-2010_02
Patent number
US07662825B2

Reaction notes

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