Hydrochloric Acid → HCID 67143095, compound

HRID 1445102Notes

Reaction equation

HRID 1445102 reaction equation
[CH2:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][N:2]1[C:11]1[N:12]=[C:13]([C:22]([N:24]2[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]2)=[O:23])[CH:14]=[C:15]2[C:19]([CH3:20])=[C:18]([CH3:21])[NH:17][C:16]=12.[ClH:30]>C(OCC)(=O)C>[ClH:30].[CH2:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][N:2]1[C:11]1[N:12]=[C:13]([C:22]([N:24]2[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]2)=[O:23])[CH:14]=[C:15]2[C:19]([CH3:20])=[C:18]([CH3:21])[NH:17][C:16]=12

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67141734HCID 67141734, compound

Product 1

HCID 67143095HCID 67143095, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A solution of [7-(3,4-dihydro-1H-isoquinolin-2-yl)-2,3-dimethyl-1H-pyrrolo[2,3-c]pyridin-5-yl]-(piperidin-1-yl)-methanone prepared in Step 2 in ethyl acetate was saturated with hydrochloric acid gas and then filtered to give the titled compound as a white solid. (Yield: 90%)

Workup

  1. filtrationfiltered

Sources & evidence

ORD record
ord-610eb0583e0444a98ab02a2e520224b9
Source dataset
uspto-grants-2010_02
Patent number
US07662832B2

Reaction notes

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