Hydrochloric Acid → HCID 86615270, compound

HRID 1445122Notes

Reaction equation

HRID 1445122 reaction equation
C(OC(=O)[N:7]([C:16]1[N:17]=[C:18]([Cl:34])[CH:19]=[C:20]2[C:24]([CH3:25])=[C:23]([CH3:26])[N:22]([CH2:27][C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=3)[C:21]=12)[CH2:8][C:9]1[CH:14]=[CH:13][C:12]([F:15])=[CH:11][CH:10]=1)(C)(C)C.Cl>C(OCC)(=O)C>[ClH:34].[CH2:27]([N:22]1[C:21]2=[C:16]([NH:7][CH2:8][C:9]3[CH:10]=[CH:11][C:12]([F:15])=[CH:13][CH:14]=3)[N:17]=[C:18]([Cl:34])[CH:19]=[C:20]2[C:24]([CH3:25])=[C:23]1[CH3:26])[C:28]1[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86615268HCID 86615268, compound

Product 1

HCID 86615270HCID 86615270, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A solution of (1-benzyl-5-chloro-2,3-dimethyl-1H-pyrrolo[2,3-c]pyridin-7-yl)-(4-fluorobenzyl)-carbamic acid tert-butyl ester prepared in Step 3 in ethyl acetate was saturated with hydrochloric acid gas and then filtered. The resulting solid was dried under reduced pressure to give 23.5 mg of the titled compound as a white solid.

Workup

  1. filtrationfiltered
  2. customThe resulting solid was dried under reduced pressure

Sources & evidence

ORD record
ord-bf8fb293d0e24a8f92be7195497921ef
Source dataset
uspto-grants-2010_02
Patent number
US07662832B2

Reaction notes

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