4-Methoxybenzyl alcohol → 1-[(4-Methoxyphenyl)methyl]-1H-pyrrole-2,5-dione

HRID 1445690Notes

Reaction equation

HRID 1445690 reaction equation
C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.CCOC(/N=N/C(OCC)=O)=O.[CH3:32][O:33][C:34]1[CH:35]=[CH:36][C:37]([CH2:40]O)=[CH:38][CH:39]=1.[C:42]1(=[O:48])[NH:46][C:45](=[O:47])[CH:44]=[CH:43]1>>[CH3:32][O:33][C:34]1[CH:39]=[CH:38][C:37]([CH2:40][N:46]2[C:42](=[O:48])[CH:43]=[CH:44][C:45]2=[O:47])=[CH:36][CH:35]=1

Participants

5

Reactant 4

HCID 77384-Methoxybenzyl alcoholHCID 10935MaleimideHCID 11776TriphenylphosphineHCID 5462977Diethyl azodicarboxylate

Product 1

HCID 27378371-[(4-Methoxyphenyl)methyl]-1H-pyrrole-2,5-dione

Procedure

Reagents: Ph3P (1.31 g, 5 mmol), DEAD (0.8 ml, 5 mmol), p-methoxybenzyl alcohol (0.93 ml, 7.5 mmol) and maleimide (0.48 g, 5 mmol).

Sources & evidence

ORD record
ord-8b0446dbe8f54a868713ca950fd8ab40
Source dataset
uspto-grants-2010_02
Patent number
US07666885B2

Reaction notes

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