Maleimide → ethyl maleimidoacetate

HRID 1445692Notes

Reaction equation

HRID 1445692 reaction equation
C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.CCOC(/N=N/C(OCC)=O)=O.[CH3:32][CH2:33][O:34][C:35]([CH2:37]O)=[O:36].[C:39]1(=[O:45])[NH:43][C:42](=[O:44])[CH:41]=[CH:40]1>>[CH2:33]([O:34][C:35]([CH2:37][N:43]1[C:39](=[O:45])[CH:40]=[CH:41][C:42]1=[O:44])=[O:36])[CH3:32]

Participants

5

Reactant 4

HCID 10935MaleimideHCID 11776TriphenylphosphineHCID 12184Ethyl GlycolateHCID 5462977Diethyl azodicarboxylate

Product 1

HCID 6539156ethyl maleimidoacetate

Procedure

Reagents: Ph3P (1.31 g, 5 mmol), DEAD (0.8 ml, 5 mmol), ethyl glycollate (0.71 ml, 7.5 mmol) and maleimide (0.48 g, 5 mmol).

Sources & evidence

ORD record
ord-28f621f74cd34f068877eb53f69ca794
Source dataset
uspto-grants-2010_02
Patent number
US07666885B2

Reaction notes

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