Tetrahydrofuran → 2-[4-(5-Pyrimidin-2-ylpent-1-enylsulfonyl)piperazin-1-yl]-5-(2,2,2-trifluoroethoxy)pyrimidine
Reaction equation
[CH2:53]1[O:54][CH2:55][CH2:56][CH2:57]1.[CH3:1][S:2](=[O:3])(=[O:4])[N:5]1[CH2:6][CH2:7][N:8]([c:11]2[n:12][cH:13][c:14]([O:17][CH2:18][C:19]([F:20])([F:21])[F:22])[cH:15][n:16]2)[CH2:9][CH2:10]1.[CH3:24][Si:25]([N-:26][Si:27]([CH3:28])([CH3:29])[CH3:30])([CH3:31])[CH3:32].[Li+:23].[P:33]([Cl:34])([O:35][CH2:36][CH3:37])([O:38][CH2:39][CH3:40])=[O:41].[n:42]1[c:43]([CH2:48][CH2:49][CH2:50][CH:51]=[O:52])[n:44][cH:45][cH:46][cH:47]1>>[CH:1]([S:2](=[O:3])(=[O:4])[N:5]1[CH2:6][CH2:7][N:8]([c:11]2[n:12][cH:13][c:14]([O:17][CH2:18][C:19]([F:20])([F:21])[F:22])[cH:15][n:16]2)[CH2:9][CH2:10]1)=[CH:51][CH2:50][CH2:49][CH2:48][c:43]1[n:42][cH:47][cH:46][cH:45][n:44]1Participants
7
Reactant 6
Product 1
Sources & evidence
- ORD record
- ord-008c1d3dcdc84208aba4e0623efb60dd
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (9/10)
Reaction notes
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