Potassium Carbonate → HCID 12895163, compound

HRID 1447137Notes

Reaction equation

HRID 1447137 reaction equation
[C:1]([C:6]1[NH:7][C:8]([CH3:16])=[C:9]([CH2:12][CH2:13][CH2:14][CH3:15])[C:10]=1[OH:11])([O:3][CH2:4][CH3:5])=[O:2].[CH2:17]([CH:19]1[O:21][CH2:20]1)Br.C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[C:1]([C:6]1[NH:7][C:8]([CH3:16])=[C:9]([CH2:12][CH2:13][CH2:14][CH3:15])[C:10]=1[O:11][CH2:17][CH:19]1[O:21][CH2:20]1)([O:3][CH2:4][CH3:5])=[O:2]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 18430EpibromohydrinHCID 586077HCID 586077, compound

Product 1

HCID 12895163HCID 12895163, compoundYield 93.8%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
50 °C

Procedure

Using the method described in Example V, 35 g of 2-carboethoxy-3-hydroxy-4-butyl-5-methyl-pyrrole, 32 g of epibromohydrin and 41 g of dry potassium carbonate in 100 ml of N,N-dimethylformamide, when heated at 50° C. for 8 hours, give 41 g of 1-(2-carboethoxy-4-butyl-5-methyl-pyrrol-3-oxy)-2,3-epoxypropane, of melting point 125°-127° C.

Sources & evidence

ORD record
ord-d4f55c6c373d40bb9d4df60cbca273f0
Source dataset
uspto-grants-1982_02
Patent number
US04315939

Reaction notes

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