Stearoyl chloride → HCID 13156318, compound

HRID 1447169Notes

Reaction equation

HRID 1447169 reaction equation
[CH:1]1[N:9]2[C:4]([NH:5][NH:6][C:7]3[CH:13]=[CH:12][CH:11]=[CH:10][C:8]=32)=[N:3][N:2]=1.[C:14](Cl)(=[O:32])[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH3:31]>CN(C)C=O>[C:14]([N:5]1[C:4]2=[N:3][N:2]=[CH:1][N:9]2[C:8]2[CH:10]=[CH:11][CH:12]=[CH:13][C:7]=2[N:6]1[C:14](=[O:32])[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH3:31])(=[O:32])[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH3:31]

Participants

4

Reactant 2

HCID 8212Stearoyl chlorideHCID 135503117HCID 135503117, compound

Product 1

HCID 13156318HCID 13156318, compoundYield 45%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
60 °C

Procedure

A mixture of 5 g (0.029 mole) of 4,5-dihydro-s-triazolo[3,4-c]benzo-as-triazine, 2 g (0.066 mole) of stearoyl chloride and 50 ml of dry dimethyl formamide is heated at 60° C. for one hour under argon atmosphere. The reaction mixture is poured onto ice and the product is filtered off. 8 g (45%) of the title compound are obtained; m.p.: 77°-78° C.

Workup

  1. additionThe reaction mixture is poured onto ice
  2. filtrationthe product is filtered off

Sources & evidence

ORD record
ord-c517e905ddca4215a7e125d5420d5cb7
Source dataset
uspto-grants-1982_02
Patent number
US04316022

Reaction notes

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