Hydrochloric Acid → HCID 135737565, compound

HRID 1448193Notes

Reaction equation

HRID 1448193 reaction equation
[OH:1][C:2]1[C:3]2[C:4]3[N:5]([N:13]=[C:14]([CH2:16][OH:17])[CH:15]=3)[C:6](=[O:12])[NH:7][C:8]=2[CH:9]=[CH:10][CH:11]=1.[CH3:18]I.Cl>[Na].CO>[OH:17][CH2:16][C:14]1[CH:15]=[C:4]2[N:5]([C:6](=[O:12])[NH:7][C:8]3[CH:9]=[CH:10][CH:11]=[C:2]([O:1][CH3:18])[C:3]=32)[N:13]=1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 6328Methyl iodideHCID 135737578HCID 135737578, compound

Product 1

HCID 135737565HCID 135737565, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 5360545SodiumSolvent

Procedure

To 4.2 g of 10-hydroxy-2-(hydroxymethyl)pyrazolo[1,5-c]quinazoline-5(6H)-one in a solution of 0.58 g sodium dissolved in 100 ml dry methanol is added 2.9 g of methyl iodide. After stirring for 3 hours at 50°, the reaction is neutralized with one equivalent of 1 N hydrochloric acid, evaporated and the residue recrystallized from absolute ethanol to give the title compound.

Workup

  1. customevaporated
  2. customthe residue recrystallized from absolute ethanol

Sources & evidence

ORD record
ord-39d133a773d741cd984c0d4d35e3d02c
Source dataset
uspto-grants-1979_12
Patent number
US04179561

Reaction notes

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