反应详情

温度

0 °C

A solution of (2-formyl-1-pyrryl)acetic acid (0.02 m) and triethylamine (0.02 ml) in tetrahydrofuran (THF) is cooled to 0° C. While stirring, isobutyl chloroformate (0.02 m) is added and the temperature is maintained at 0° C. for 15 minutes. A cold solution of 7-amino-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (0.02 m) and triethylamine (0.02 m) in 50% aqueous THF is added to the previous solution with stirring.

1. stirringwith stirring