Benzyl Alcohol → HCID 19977709, compound

HRID 1449440Notes

Reaction equation

HRID 1449440 reaction equation
[CH2:1](O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H-].[Na+].[CH2:11]([O:13][C:14]1[CH:19]=[C:18]([CH3:20])[N:17]=[C:16](S(C)(=O)=O)[N:15]=1)[CH3:12]>O1CCCC1>[CH2:11]([O:13][C:14]1[CH:19]=[C:18]([CH3:20])[N:17]=[C:16]([CH2:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)[N:15]=1)[CH3:12]

Participants

5

Reactant 3

HCID 244Benzyl AlcoholHCID 24758Sodium hydrideHCID 19977708HCID 19977708, compound

Product 1

HCID 19977709HCID 19977709, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To benzyl alcohol (Compound II-64) (0.35 g, 0.0016×2.0 mol) in tetrahydrofuran, sodium hydride (0.085 g, (60% in mineral oil), 0.0016×1.3 mol) and 4-ethoxy-6-methyl-2-(methylsulfonyl)pyrimidine (Compound III-44) (0.35 g, 0.0016 mol) prepared as described in Reference synthesis example 1 below were successively added and the solution was allowed to react for about 1 hour at room temperature.

Workup

  1. customas described in Reference synthesis example 1
  2. additionbelow were successively added
  3. customto react for about 1 hour at room temperature

Sources & evidence

ORD record
ord-dff60029e2a7430f88e578b9650c89ba
Source dataset
uspto-grants-1997_02
Patent number
US05599770

Reaction notes

Loading…