Phenylethanolamine → HCID 54069235, compound

HRID 1449821Notes

Reaction equation

HRID 1449821 reaction equation
O1CCCC1.[NH2:6][CH2:7][CH:8]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[OH:9].Br[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][O:29][C:30](=[O:40])[CH2:31][CH2:32][CH2:33][C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1>C(N(CC)CC)C>[OH:9][CH:8]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[CH2:7][NH:6][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][O:29][C:30](=[O:40])[CH2:31][CH2:32][CH2:33][C:34]1[CH:35]=[CH:36][CH:37]=[CH:38][CH:39]=1

Participants

5

Reactant 3

HCID 1000PhenylethanolamineHCID 8028TetrahydrofuranHCID 54093051HCID 54093051, compound

Product 1

HCID 54069235HCID 54069235, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

According to method I (tetrahydrofuran, reflux 4 days) from 2-amino-1-phenylethanol and (12-bromo-1-dodecyl)4-phenylbutanoate. Working up by means of chromatography (ethyl acetate/petroleum ether 60-80/triethylamine 6:4:1). Recrystallized from diethyl ether. Melting point: 73°-74° C.

Workup

  1. customRecrystallized from diethyl ether

Sources & evidence

ORD record
ord-414e015e73db497199826b02b17ae626
Source dataset
uspto-grants-1997_02
Patent number
US05599966

Reaction notes

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