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150 mg (0.3 mmol) of 3-{3-[2,2,2-trifluoro-1-(4-methoxy-benzyloxy)-1-trifluoromethyl-ethyl]-phenoxy}-propan-1-ol and 73 mg (0.38 mmol) of 3-(3-hydroxy-phenyl)-propionic acid ethyl ester (CAS 34708-60-6) in 4 mL of THF were treated with 117 mg (0.44 mmol) of triphenylphosphine. The solution was cooled to 0° C. and treated with 88 μL (0.44 mmol) of DIAD. The mixture was stirred at room temperature overnight, the solvent was evaporated and the crude mixture was purified by column chromatography on silica gel with a gradient of EtOAc/n-heptane 1:5 to 1:3 to yield 110 mg (52%) of 3-[3-(3-{3-[2,2,2-trifluoro-1-(4-methoxy-benzyloxy)-1-trifluoromethyl-ethyl]-phenoxy}-propoxy)-phenyl]-propionic acid ethyl ester as a colorless liquid, MS: 614 (M)+.

1. customthe solvent was evaporated
2. customthe crude mixture was purified by column chromatography on silica gel with a gradient of EtOAc/n-heptane 1:5 to 1:3