Hydrochloric Acid → HCID 178494817, compound

HRID 1453545Notes

Reaction equation

HRID 1453545 reaction equation
[OH-].[Li+].[Br:3][C:4]1[NH:8][C:7]([C:9]([O:11]C)=[O:10])=[C:6](/[CH:13]=[CH:14]/[O:15][CH3:16])[N:5]=1.Cl>O.O1CCCC1>[Br:3][C:4]1[NH:8][C:7]([C:9]([OH:11])=[O:10])=[C:6](/[CH:13]=[CH:14]/[O:15][CH3:16])[N:5]=1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 178494819HCID 178494819, compound

Product 1

HCID 178494817HCID 178494817, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

A solution of 2.20 g lithium hydroxide in 175 ml of water is added to a solution of 3.50 g methyl 2-bromo-5-(trans-2-methoxy-vinyl)-3H-imidazole-4-carboxylate in 140 ml of tetrahydrofuran. The solution is stirred for 4 h at ambient temperature. Then 92 ml aqueous 1 M hydrochloric acid are added, and the solution is cooled in the ice bath. The precipitate is separated off, washed with water and dried.

Workup

  1. customThe precipitate is separated off
  2. washwashed with water
  3. customdried

Sources & evidence

ORD record
ord-24388336b88d437a81d2d98c9f5e93d9
Source dataset
uspto-grants-2009_01
Patent number
US07476671B2

Reaction notes

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