Triethylamine → HCID 178483054, compound

HRID 1453552Notes

Reaction equation

HRID 1453552 reaction equation
[N:1]1([C:10]2[N:18]=[C:17](Cl)[N:16]=[C:15]3[C:11]=2[N:12]=[CH:13][NH:14]3)[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[CH:2]1.[CH2:20]([N:22](CC)[CH2:23]C)C>CN(C)C=O>[N:1]1([C:10]2[N:18]=[C:17]([N:22]([CH3:23])[CH3:20])[N:16]=[C:15]3[C:11]=2[N:12]=[CH:13][NH:14]3)[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[CH:2]1

Participants

4

Reactant 2

HCID 8471TriethylamineHCID 178478376HCID 178478376, compound

Product 1

HCID 178483054HCID 178483054, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
90 °C

Procedure

300 mg of product obtained in stage 1 above are mixed with 3 ml of DMF (dimethylformamide) and 0.17 ml (1.1 equivalents) of TEA (triethylamine). The mixture is heated at 90° C. for 2 hours. The precipitate is filtered off. Purification is carried out by chromatography on silica with a CH2Cl2-MeOH—NH4OH: 90-9-9 mixture for eluent. 298 mg of expected product are obtained.

Workup

  1. filtrationThe precipitate is filtered off
  2. customPurification

Sources & evidence

ORD record
ord-4cacf908f01646c8ab84931e133ad2d4
Source dataset
uspto-grants-2009_01
Patent number
US07476670B2

Reaction notes

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