Trifluoroacetic acid → HCID 178507877, compound

HRID 1453587Notes

Reaction equation

HRID 1453587 reaction equation
[N:1]1([C:10]2[N:18]=[C:17]([N:19]3[CH2:24][CH2:23][CH:22]([NH:25]C(=O)OC(C)(C)C)[CH2:21][CH2:20]3)[N:16]=[C:15]3[C:11]=2[N:12]=[CH:13][NH:14]3)[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[CH:2]1.[F:33][C:34]([F:39])([F:38])[C:35]([OH:37])=[O:36].C1(OC)C=CC=CC=1>C(Cl)Cl>[F:33][C:34]([F:39])([F:38])[C:35]([OH:37])=[O:36].[F:33][C:34]([F:39])([F:38])[C:35]([OH:37])=[O:36].[N:1]1([C:10]2[N:18]=[C:17]([N:19]3[CH2:20][CH2:21][CH:22]([NH2:25])[CH2:23][CH2:24]3)[N:16]=[C:15]3[C:11]=2[N:12]=[CH:13][NH:14]3)[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[CH:2]1

Participants

5

Reactant 3

HCID 6422Trifluoroacetic acidHCID 7519AnisoleHCID 178452839HCID 178452839, compound

Product 1

HCID 178507877HCID 178507877, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

100 mg of product obtained in Example 22 are mixed with 3 ml of methylene chloride and 1.5 ml of trifluoroacetic acid containing 10% of anisole. The mixture is stirred at ambient temperature for 5 hours. It is concentrated to dryness and co-evaporation with toluene and then with methylene chloride is carried out. Purification is carried out by chromatography on silica with a CH2Cl2-MeOH—NH4OH: 90-9-1 mixture for eluent. 128 mg of expected product are obtained.

Workup

  1. concentrationIt is concentrated to dryness and co-evaporation with toluene
  2. customPurification

Sources & evidence

ORD record
ord-69950820b67a461c83bb7819d192f774
Source dataset
uspto-grants-2009_01
Patent number
US07476670B2

Reaction notes

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