Trifluoroacetic acid → HCID 178525679, compound

HRID 1453603Notes

Reaction equation

HRID 1453603 reaction equation
[N:1]1([C:10]2[N:18]=[C:17]([NH:19][CH2:20][CH:21]3[CH2:26][CH2:25][N:24](C(OC(C)(C)C)=O)[CH2:23][CH2:22]3)[N:16]=[C:15]3[C:11]=2[N:12]=[CH:13][NH:14]3)[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[CH:2]1.[C:34]([OH:40])([C:36]([F:39])([F:38])[F:37])=[O:35].C1(OC)C=CC=CC=1>C(Cl)Cl>[F:37][C:36]([F:39])([F:38])[C:34]([OH:40])=[O:35].[F:37][C:36]([F:39])([F:38])[C:34]([OH:40])=[O:35].[N:1]1([C:10]2[N:18]=[C:17]([NH:19][CH2:20][CH:21]3[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]3)[N:16]=[C:15]3[C:11]=2[N:12]=[CH:13][NH:14]3)[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[CH:2]1

Participants

5

Reactant 3

HCID 6422Trifluoroacetic acidHCID 7519AnisoleHCID 178451976HCID 178451976, compound

Product 1

HCID 178525679HCID 178525679, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

35 mg of the product of Example 31 are mixed with 1 ml of CH2Cl2 and 0.5 ml of TFA containing 10% of anisole. The mixture is left to stir for 2 hours at ambient temperature, followed by concentrating to dryness in the presence of toluene and of CH2Cl2. 40 mg of expected product are thus obtained.

Workup

  1. waitThe mixture is left
  2. concentrationby concentrating to dryness in the presence of toluene and of CH2Cl2

Sources & evidence

ORD record
ord-88aa826fd34049f5a8e425426af98aa2
Source dataset
uspto-grants-2009_01
Patent number
US07476670B2

Reaction notes

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