反应详情

Nicotinoyl chloride hydrochloride (356 mg, 2 mmol) and triethylamine (558 μl, 2 mmol) are added to a solution of 8-amino-4-bromoisoquinoline (intermediate 23.2, 446 mg, 0.90 mmol) in anhydrous THF (25 ml). The reaction mixture is stirred overnight, diluted with AcOEt (200 ml) and washed twice with 1N NaOH (100 ml) and then the organic phase is dried over Na2SO4 and evaporated under vacuum. The residue is purified on silica gel, eluting with AcOEt.

1. washwashed twice with 1N NaOH (100 ml)
2. dry with materialthe organic phase is dried over Na2SO4
3. customevaporated under vacuum
4. customThe residue is purified on silica gel
5. washeluting with AcOEt