Sodium Iodide → HCID 22392771, compound

HRID 1455298Notes

Reaction equation

HRID 1455298 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([O:11]C)=[O:10])=[CH:4][CH:3]=1.Cl[CH2:14][C:15]1[C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[N:18]=[C:17]([CH3:25])[CH:16]=1.C(=O)([O-])[O-].[Cs+].[Cs+].[I-].[Na+]>C1COCC1>[CH3:25][C:17]1[CH:16]=[C:15]([CH2:14][O:1][C:2]2[CH:3]=[CH:4][C:5]([CH2:8][C:9]([OH:11])=[O:10])=[CH:6][CH:7]=2)[C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[N:18]=1

Participants

6

Reactant 4

HCID 5238Sodium IodideHCID 10796Cesium carbonateHCID 518900Benzeneacetic acid, 4-hydroxy-, methyl esterHCID 115357194-(Chloromethyl)-2-methylquinoline

Product 1

HCID 22392771HCID 22392771, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of methyl (4-hydroxyphenyl)acetate (10.0 g, 60.2 mmol) in 400 mL THF was added 4-chloromethyl-2-methylquinoline (11.5 g, 60.2 mmol), cesium carbonate (29.4 g, 90.3 mmol), and sodium iodide (451 mg, 3 mmol).

Sources & evidence

ORD record
ord-73034c943c784995a14c91ce85cd2ecf
Source dataset
uspto-grants-2009_01
Patent number
US07482372B2

Reaction notes

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