反应详情

Preparation H7, Step 1: To a soultion of 3-(methoxycarbonyl)benzoic acid (800 mg, 4.4 mmol) in DMF (15 mL) at rt was added HATU (2g, 5.3 mmol), 3-aminopropanenitrile (0.33 mL, 4.4 mmol), and iPr2NEt (0.92 mL, 5.3 mmol). The mixture was stirred at rt for 16 h before water and EtOAc were added. The organic layer was separated and re-washed twice before it was collected, dried over Na2SO4, and concentrated to provide methyl 3-((2-cyanoethyl)carbamoyl)benzoate as a glassy solid (900 mg). MS found: (M+H)+=233.

1. customPreparation H7, Step 1
2. additionwere added
3. customThe organic layer was separated
4. washre-washed twice before it
5. customwas collected
6. dry with materialdried over Na2SO4
7. concentrationconcentrated