反应详情

0.42 g of 4-chlorophenylsulfonamide, 60 mg of DMAP and 0.42 g of EDC are added to a solution of 0.5 g of 4-pentyl-bicyclo[2.2.2]octane-1-carboxylic acid in 8 ml of DMF, the mixture obtained is stirred for ca. 16 h at RT and solvent from the mixture obtained is evaporated. The evaporation residue obtained is dissolved in EtAc and washed with 1 N HCl, saturated NaHCO3 solution and brine and the organic phase obtained is dried. Solvent of the organic phase obtained is evaporated and the evaporation residue obtained is subjected to chromatography. 4-Chloro-N-(4-pentyl- bicyclo[2.2.2]octane-1-carbonyl)-benzenesulfonamide is obtained in the form of a white powder;

1. customthe mixture obtained
2. customsolvent from the mixture obtained
3. customis evaporated
4. customThe evaporation residue obtained
5. dissolutionis dissolved in EtAc
6. washwashed with 1 N HCl, saturated NaHCO3 solution and brine
7. customthe organic phase obtained
8. customis dried
9. customSolvent of the organic phase obtained
10. customis evaporated
11. customthe evaporation residue obtained