1,3-Dibromobenzene → 4-(3-Bromophenyl)pyridine

HRID 1455649Notes

Reaction equation

HRID 1455649 reaction equation
[N:1]1[CH:6]=[CH:5][C:4](B(O)O)=[CH:3][CH:2]=1.[Br:10][C:11]1[CH:16]=[CH:15][CH:14]=[C:13](Br)[CH:12]=1.CCCCCC>CCOC(C)=O>[Br:10][C:11]1[CH:12]=[C:13]([C:4]2[CH:5]=[CH:6][N:1]=[CH:2][CH:3]=2)[CH:14]=[CH:15][CH:16]=1

Participants

5

Reactant 3

HCID 79271,3-DibromobenzeneHCID 8058HexaneHCID 2734379(Pyridin-4-yl)boronic acid

Product 1

HCID 131504024-(3-Bromophenyl)pyridine

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Prepared according to the general procedure Coupling-1 using 4-pyridinylboronic acid and 1,3-dibromobenzene. Flash chromatography (Hexane:EtOAc, 70:30) afforded the title compound.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-11777189074d4987b67e942c04f208c1
Source dataset
uspto-grants-2009_01
Patent number
US07482456B2

Reaction notes

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