Hydrochloric Acid → HCID 22867045, compound

HRID 1456619Notes

Reaction equation

HRID 1456619 reaction equation
[OH-:1].[Li+].[CH:3]1[C:15]2[CH2:14][C:13]3[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=3)[C:7]=2[CH:6]=[CH:5][C:4]=1[O:16][CH:17]1[CH2:21][CH:20]([C:22]([O:24]C)=[O:23])[NH:19][C:18]1=[O:26].Cl>O.O1CCCC1>[CH:3]1[C:15]2[CH2:14][C:13]3[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=3)[C:7]=2[CH:6]=[CH:5][C:4]=1[O:16][CH:17]([C:18]([OH:26])=[O:1])[CH2:21][C@@H:20]([C:22]([OH:24])=[O:23])[NH2:19]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 22107118HCID 22107118, compound

Product 1

HCID 22867045HCID 22867045, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Conditions

Temperature
60 °C

Procedure

A mixture of lithium hydroxide (0.117 g) in water (1.5 ml) and tetrahydrofuran (4.7 ml) was treated with methyl 3-(2-fluorenoxy)-2-pyrrolidone-5-carboxylate (0.526 g), and heated to 60° C. After about 3.3 hours, the reaction mixture was allowed to cool to room temperature. The reaction mixture was treated with 5N HCl (976 ml). The resulting colloidal suspension was sonicated for ten minutes. The insolubles were collected by filtration, washed with 1:1 THF:water (10 ml), THF (10 ml), and water (10 ml). The insolubles were dried overnight in at vacuum oven at 60° C. to afford the title compound.

Workup

  1. temperatureto cool to room temperature
  2. customThe resulting colloidal suspension was sonicated for ten minutes
  3. filtrationThe insolubles were collected by filtration
  4. washwashed with 1:1 THF
  5. customThe insolubles were dried overnight in at vacuum oven at 60° C.

Sources & evidence

ORD record
ord-7ff44da393334d709230b9d0ae5500fb
Source dataset
uspto-grants-1998_12
Patent number
US05843997

Reaction notes

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