反应详情

0.30 g (7.50 mmol) of 60% strength sodium hydride are added in portions to 0.86 g (5.00 mmol) of 2-(4-hydroxyphenyl)pyrimidine in 40 ml of dimethylformamide, and the mixture is stirred at room temperature for 15 minutes. 1.45 g (7.50 mmol) of 1-bromooctane are subsequently added, the mixture is stirred overnight, poured into ice water and filtered, and the residue is purified by chromatography (silica gel/dichloromethane) and by recrystallization from acetonitrile, giving 0.93 g of 2-(4-octyloxyphenyl)pyrimidine. ##STR32##

1. stirringthe mixture is stirred overnight
2. filtrationfiltered
3. customthe residue is purified by chromatography (silica gel/dichloromethane) and by recrystallization from acetonitrile