Hydrochloric Acid → HCID 19026075, compound

HRID 1460274Notes

Reaction equation

HRID 1460274 reaction equation
[CH2:1]([NH2:6])[CH2:2][CH:3]([CH3:5])[CH3:4].[Cl:7][CH2:8][CH2:9][CH2:10][N:11]1[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1.[ClH:17]>C(O)C>[ClH:7].[ClH:17].[CH3:4][CH:3]([CH3:5])[CH2:2][CH2:1][NH:6][CH2:8][CH2:9][CH2:10][N:11]1[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 7894IsoamylamineHCID 79625Piperidine, 1-(3-chloropropyl)-

Product 1

HCID 19026075HCID 19026075, compoundYield 64%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Conditions

Temperature
120 °C

Procedure

A mixture of 23.2 ml of isoamylamine and 16.17 g of 1-(3-chloropropyl)piperidine was heated to 120° C. for 2 hours. The reaction mixture was then dissolved in 100 ml of ethanol. To this ethanol solution was added 17 ml of conc. hydrochloric acid. The mixture was allowed to stand overnight at room temperature. The precipitated crystals were collected, washed with ethanol, and dried to give 14.70 g of 1-[3-(3-methylbutylamino)propyl]piperidine dihydrochloride as a white crystalline product.

Workup

  1. customThe precipitated crystals were collected
  2. washwashed with ethanol
  3. customdried

Sources & evidence

ORD record
ord-2016a8ea5ee04c74882c1fdcbd964003
Source dataset
uspto-grants-1991_12
Patent number
US05070196

Reaction notes

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