反应详情

温度

100 °C

To a stirred solution of 1-fluoro-2-nitrobenzene (14.1 g, 0.1 mol) and triethylamine (14 ml, 0.1 mol) in DMF (150 ml) was added phenethylamine (12.1 g, 0.1 mol). The mixture was now heated to 100° C., and the reaction was monitored by TLC. After the reaction was completed (2 h) the solvent was removed by evaporation in vacuo. The residue was partitioned between 0.5N aqueous HCl (100 ml) and ether (100 ml). The organic phase was washed with water, dried and evaporated to give the title compound as a yellow oil.

1. custom(2 h)
2. customwas removed by evaporation in vacuo
3. customThe residue was partitioned between 0.5N aqueous HCl (100 ml) and ether (100 ml)
4. washThe organic phase was washed with water
5. customdried
6. customevaporated