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HRID1461808

反应详情

EQUATION

反应方程式

HRID 1461808 的结构方程式

REACTANTS

反应物

3
结构：CNC
HCID674

Dimethylamine

C2H7N

结构：O=C([O-])[O-].[K+].[K+]
HCID11430

Potassium Carbonate

CK2O3

结构：CCC(Cc1ccccc1)(C(=O)c1ccc(F)cc1)N(C)C
HCID19360599

2-Benzyl-2-(dimethylamino)-1-(4-fluorophenyl)butan-1-one

C19H22FNO

PRODUCTS

生成物

1
结构：CCC(Cc1ccccc1)(C(=O)c1ccc(N(C)C)cc1)N(C)C
HCID164106

2-Benzyl-2-(dimethylamino)-1-[4-(dimethylamino)phenyl]butan-1-one

C21H28N2O

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

A stirred autoclave is filled with 50 g (0.167 mol) of 1-(4-fluorophenyl)-2-dimethylamino-2-benzylbutan-1-one (crude product from B), 300 ml of dimethylformamide and 23.1 g (0.167 mol) of potassium carbonate. 22.6 g (0.5 mol) of dimethylamine are then added under pressure (3-4 bar). The mixture is heated to 100° and stirred at this temperature for 24 hours.

WORKUP

后处理

  1. temperatureThe mixture is heated to 100°