Hydrochloric Acid → Diethyl 2-(3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)phenethyl)malonate
Reaction equation
[C:1](=[O:2])([O-:3])[O-:4].[C:7]([CH2:8][C:9](=[O:10])[O:11][CH2:12][CH3:13])(=[O:14])[O:15][CH2:16][CH3:17].[ClH:45].[Cs+:5].[Cs+:6].[F:18][c:19]1[c:20](-[c:27]2[s:28][c:29]3[n:30][c:31]([C:36]4([c:39]5[cH:40][cH:41][cH:42][cH:43][cH:44]5)[CH2:37][CH2:38]4)[cH:32][cH:33][c:34]3[n:35]2)[cH:21][cH:22][c:23]([CH:25]=[CH2:26])[cH:24]1.[O:46]=[CH:47][N:48]([CH3:49])[CH3:50]>>[C:7]([CH:8]([C:9](=[O:10])[O:11][CH2:12][CH3:13])[CH2:26][CH2:25][c:23]1[cH:22][cH:21][c:20](-[c:27]2[s:28][c:29]3[n:30][c:31]([C:36]4([c:39]5[cH:40][cH:41][cH:42][cH:43][cH:44]5)[CH2:37][CH2:38]4)[cH:32][cH:33][c:34]3[n:35]2)[c:19]([F:18])[cH:24]1)(=[O:14])[O:15][CH2:16][CH3:17]Participants
7
Reactant 6
Product 1
Sources & evidence
- ORD record
- ord-ff8650d0d3e8464c96d476c94b650dff
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (9/10)
Reaction notes
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