Acetic Acid → HCID 12882232, compound

HRID 1462031Notes

Reaction equation

HRID 1462031 reaction equation
[C-:1]#[N:2].[K+].C(O)(=O)C.[NH:8]([C:15]1[CH:16]=[C:17]([CH:20]=[CH:21][CH:22]=1)[CH:18]=[O:19])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.Cl>C(O)C>[NH:8]([C:15]1[CH:16]=[C:17]([CH:20]=[CH:21][CH:22]=1)[CH:18]([OH:19])[C:1]#[N:2])[C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1

Participants

6

Reactant 4

HCID 176Acetic AcidHCID 313Hydrochloric AcidHCID 9032Potassium CyanideHCID 12850342HCID 12850342, compound

Product 1

HCID 12882232HCID 12882232, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1.5 g of KCN and 1.8 ml of acetic acid were added to 2.5 g of the aldehyde thus obtained dissolved 40 ml of ethanol and then left overnight under stirring. Then, the reaction mixture was poured into 100 ml of 2N-HCl and the extraction was effected with benzene. After washing with NaCl aqueous solution, the benzene layer was condensed to yield 2.7 g of 3-anilino-α-cyanobenzylalcohol.

Workup

  1. customthus obtained
  2. extractionthe extraction
  3. washAfter washing with NaCl aqueous solution
  4. customcondensed

Sources & evidence

ORD record
ord-398c759f12914f9ea691e45f87fc466e
Source dataset
uspto-grants-1984_07
Patent number
US04457940

Reaction notes

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