Methane → HCID 178430864, compound

HRID 1462453Notes

Reaction equation

HRID 1462453 reaction equation
[CH3:1][C:2]1[N:3]=[C:4]2[CH2:10][C:9]3[CH:11]=[CH:12][CH:13]=[CH:14][C:8]=3[NH:7][C:6](=[O:15])[N:5]2[CH:16]=1.[CH3:17][N:18]1[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]1.C>C(Cl)Cl>[CH3:1][C:2]1[N:3]=[C:4]([CH2:10][C:9]2[CH:11]=[CH:12][CH:13]=[CH:14][C:8]=2[NH:7][C:6]([N:21]2[CH2:22][CH2:23][N:18]([CH3:17])[CH2:19][CH2:20]2)=[O:15])[NH:5][CH:16]=1

Participants

5

Reactant 3

HCID 297MethaneHCID 531671-MethylpiperazineHCID 13474164HCID 13474164, compound

Product 1

HCID 178430864HCID 178430864, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A mixture of 16 g of 2-methyl-11H-imidazo[1,2-c][1,3]bezodiazepine-5-(6H)-one, 9.58 g of N-methylpiperazine and 160 ml of methylene chloride is stirred at room temperature overnight. The mixture is decolorized with charcoal and evaporated to dryness. The residue is crystallized from methanol-ether to give 1-[2-(4-methyl-2-imidazolylmethyl) phenylcarbamoyl]-4-methylpiperazine, m.p. 177°-179°.

Workup

  1. customevaporated to dryness
  2. customThe residue is crystallized from methanol-ether

Sources & evidence

ORD record
ord-87237b130125474ea7a7582873bfdbcf
Source dataset
uspto-grants-1984_07
Patent number
US04460587

Reaction notes

Loading…